{"id":638,"date":"2022-04-25T21:33:19","date_gmt":"2022-04-25T21:33:19","guid":{"rendered":"https:\/\/newsletters.aans.org\/tumor\/?page_id=638"},"modified":"2022-04-26T14:39:54","modified_gmt":"2022-04-26T14:39:54","slug":"laser-interstitial-thermotherapy-studies-currently-open-2022","status":"publish","type":"page","link":"https:\/\/newsletters.aans.org\/tumor\/tumor-news-spring-2022\/laser-interstitial-thermotherapy-studies-currently-open-2022\/","title":{"rendered":"Laser Interstitial Thermotherapy Studies Currently Open – 2022"},"content":{"rendered":"

Andrew Sloan, MD, & Ian Lee MD<\/p>\n

 <\/p>\n

There are currently 5 Studies of LITT for Adults with Brain Tumors with primary and recurrent gliomas as well as brain metastasis as indicated in the Table below.\u00a0 Below, we highlight 2 of them (for Brain metastasis and recurrent glioma) in more detail.<\/p>\n\n\n\n\n\n\n\n\n
TITLE<\/strong><\/td>\nCONDITION<\/strong><\/td>\nTREATMENT<\/strong><\/td>\nLOCATION<\/strong><\/td>\n<\/tr>\n
LITT + Hypofractionated RT for newly diagnosed Glioma<\/td>\nNewly diagnosed Glioma<\/td>\nLITT + Hypofractionated RT<\/td>\nUniversity of MD Proton Center,;UCH Kaufman Cancer Center<\/td>\n<\/tr>\n
Expedited LITT + Chemradiation for newly diagnosed HGG<\/td>\nNewly diagnosed Glioma<\/td>\nLITT + Hypofractionated RT + TMZ<\/td>\nCase Comprehensive Cancer Center<\/td>\n<\/tr>\n
LITT + Hypofractionalted RT for Recurrent\u00a0 Glioma<\/td>\nRecurrent Glioma<\/td>\nLITT + Hypofractionated RT<\/td>\nUniversity of Maryland, UCH Kaufman Cancer Center, Baltimore Washington Medical Center<\/td>\n<\/tr>\n
LITT combined with Checkpoint Inhibitor for recurrent GBM<\/td>\nRecurrent GBM<\/td>\nLITT + Neoadjuvant Pembrolizumab<\/td>\nUniversisty Hospitals-Seidman Cancer Center; Case Comprehensive Cancer Center<\/td>\n<\/tr>\n
LITT + Pembrolizumab in Recurrent Brain Metastasis<\/td>\nRecurrent Brain Metastasis<\/td>\nLITT + Pembrolizumab<\/td>\nUniversity of Florida, Jacksonville; McKnight Brain Institute, UF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

    \n
  1. LITT and Pembrolizumab in Recurrent Brain Metastasis <\/strong><\/li>\n<\/ol>\n

    B<\/em>rief Summary:<\/em><\/p>\n

    This is an open-label, historically controlled pilot study investigating the immune effect of Laser Interstitial ThermotHerapy (LITT)+ pembrolizumab in adult patients with a primary cancer approved by the FDA for treatment with an immune-checkpoint inhibitor who have recurrent brain metastasis after prior stereotactic radiosurgery (SRS).<\/p>\n

    Adult patients with a primary cancer approved by the FDA for treatment with an immune-checkpoint inhibitor who have recurrent brain metastasis that have failed stereotactic radiosurgery treatment will be screened. They will sign consent and complete screening procedures. Each patient will be scheduled to undergo biopsy and LITT treatment. Within two weeks of surgery, patients will begin receiving pembrolizumab every three weeks. Pembrolizumab infusions will continue until brain met recurrence per RANO for Brain Mets or up to two years, whichever comes first. Blood samples will be collected for immune monitoring. Tumor tissue will be collected for immune and genomic studies. Approximately 21 patients will be enrolled to accrue 15 evaluable subjects. Patients will be followed for survival data for one year or until death, whichever comes first.<\/p>\n

    Location:\u00a0 University of Florida, Gainesville, FL<\/strong><\/p>\n

     <\/p>\n

    2. Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (rGBM)<\/strong><\/p>\n

    Brief Summary:<\/em><\/p>\n

    The purpose of this study is to test the side effects and efficacy of using Laser Interstitial Thermotherapy (LITT) combined with Pembrolizumab. LITT is a minimally invasive surgical technique that uses a laser to heat brain tumors.<\/p>\n

    Pembrolizumab is an investigational (experimental) drug that works by helping participants’ immune system work correctly to detect and fight cancer cells. Pembrolizumab is experimental because it is not approved by the Food and Drug Administration (FDA), for this use, though it is approved to treat other cancers.<\/p>\n

     <\/p>\n

    Location:\u00a0 University Hospitals-Seidman Cancer Center & Case Comprehensive Cancer Center, Cleveland, OH<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

    Andrew Sloan, MD, & Ian Lee MD   There are currently 5 Studies of LITT for Adults with Brain Tumors with primary and recurrent gliomas as well as brain metastasis as indicated in the Table below.\u00a0 Below, we highlight 2 of them (for Brain metastasis and recurrent glioma) in more detail. TITLE CONDITION TREATMENT LOCATION […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":596,"menu_order":9,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-638","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nLaser Interstitial Thermotherapy Studies Currently Open - 2022 - Tumor News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/newsletters.aans.org\/tumor\/tumor-news-spring-2022\/laser-interstitial-thermotherapy-studies-currently-open-2022\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Laser Interstitial Thermotherapy Studies Currently Open - 2022 - Tumor News\" \/>\n<meta property=\"og:description\" content=\"Andrew Sloan, MD, & Ian Lee MD   There are currently 5 Studies of LITT for Adults with Brain Tumors with primary and recurrent gliomas as well as brain metastasis as indicated in the Table below.\u00a0 Below, we highlight 2 of them (for Brain metastasis and recurrent glioma) in more detail. 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