CNS 2019 Highlights

Saturday, October 19

  • CNS2019Functional Neurosurgery Update: Emerging Concepts
    Ellen Air, Casey Halpern
    and John Rolston moderated the functional neurosurgery update. Faculty included Aviva Abosch, Raag Airan, Nicholas M. Barbaro, Stephan Chabardes, Edward F. Chang, Shabbar F. Danish, W. Jeffrey Elias, Robert S. Fisher, Kelly D. Foote, Wayne Goodman, Paul S. Larson, Andres M. Lozano, Mohammed Maarouf, Kai J. Miller, Francisco A. Ponce, Robert M. Richardson, Michael Schulder, Sameer A. Sheth and Peter A. Tass.

Sunday, October 20

  • Virtual and Augmented Reality: Science and Clinical Applications
    Walter Jean
    and Cameron McIntyre moderated the course providing an in-depth review of technologies currently available for pre- and intraoperative brain anatomy and pathology visualization.

Monday, October 21

  • Guidelines for DBS for Parkinson’s Disease and Neuroablation for Pain
    Clement Hamani
    and Ahmed Raslan directed the course reviewing recently published guidelines, including the evidence basis and rationale for choosing one approach or another.
  • Section on Stereotactic and Functional Neurosurgery
    Ellen Air and Nitin Tandon moderated a session on the future of preoperative non-invasive mapping using novel technologies. Speakers included:
  • Hui M. Khoo: EEG-fMRI and Network-based Mapping for Localizing Epilepsy Foci
  • Raag Airan: Focused US for Non-invasively Probing Brain Circuits
  • Dario J. Englot: Connectivity-based Preoperative Functional Mapping to Predict Outcomes

The session continued with oral presentations, including:

  • PAPER OF THE YEAR: Long-Term Follow-up Study of MRI-Guided Bilateral Anterior Capsulotomy in Patients With Refractory Anorexia Nervosa – Bomin Sun
  • Early Feasibility Study of a Neurostimulator to Create Artificial Vision – Nader Pouratian
  • BEST CLINICAL TALK: Distributed Global Functional Connectivity Networks Predict Responsiveness to L-DOPA and Subthalamic Deep Brain Stimulation – Chengyuan Wu
  • RESIDENT AWARD: A Fully Implantable Brain Machine Interface for Volitional Hand Grasp Restoration in Cervical Quadriplegia – Iahn Cajigas
  • Tackling Big Data in Human Intracranial EEG Recordings – Patrick J. Karas
  • Thalamic Arousal Network Disturbances in Temporal Lobe Epilepsy and Improvement After Surgery – Dario J. Englot
  • Sphenopalatine Ganglion Stimulation Upregulates Transport of Intra-arterial Temozolomide Across the Blood-Brain Barrier – Thana N. Theofanis
  • BEST OPERATIVE TALK: Stereotactic ROBOT-assisted Deep Brain Stimulation Workflow: Incorporating the ROSA-Brain System into the Functional Neurosurgical Practice – Amir H. Faraji
  • Vagal Nerve Stimulator Lead Revision Using Needle-Tip Cautery: Case Series, Literature Review, and Technical Note – Vyacheslav I. Makler
  • Robotic Orthogonal Implantation of Responsive Neurostimulation (RNS) Depth Electrodes in Patients with Unilateral Mesial Temporal Lobe Seizure Onset – Alvin Y. Chan
  • Accuracy of SEEG Electrodes Implanted in Lateral Position Versus Supine Position – Caio M. Matias
  • Challenging Cases in Epilepsy Surgery: Operative Techniques and Case-based Discussions
    Joseph Neimat moderated the session in which faculty presented challenging epilepsy surgery cases and discussed them with the audience. Faculty included Ausaf A. Bari, Sharona Ben-Haim, Jorge A. Gonzalez-Martinez, Robert A. McGovern and Jin-song Wu.
  • The International Functional Neurosurgery Symposium
    Jorge A. Gonzalez-Martinez and Makoto Taniguchi moderated the session, which included:
  • Masaki Iwasaki: Current Status and Future Perspective of Epilepsy Surgery in Japan
  • Hui Ming Khoo: Advances in Epilepsy Research
  • Takaomi Taira: Stereotactic Lesioning for Dystonia and Movement Disorders

Tuesday, October 22

  • Clinical Trials in Movement Disorder Surgery
    Sharona Ben-Haim
    and Ashwin Viswanathan directed the course, which identified key trials and levels of evidence for movement disorder surgery, described relative advantages and evidence supporting DBS and lesion procedures as well as identified ongoing trials and new device platforms for DBS and lesion surgery.
  • Gross-CNS-2019-Plenary-SessionGeneral Scientific Session – Controversies: Are RCTs Necessary to Validate a Novel Therapy?
    Robert Gross led a plenary session discussion on the role of clinical trials with Richard Fessler making the case that RCTs are not necessary and might not be ethical and Gary Steinberg taking the position that RCTs are always necessary for new therapies.
  • Section on Stereotactic and Functional Neurosurgery
    Guy McKhann and Doris Wang moderated the sessions which included the following oral presentations:
  • Action Observation and Execution Differentially Modulate Basal Ganglia-cortical Activity in Humans – Mahsa Malekmohammadi,
  • Resting-state SEEG May Help Localize Epileptogenic Brain Regions – Sarah Goodale
  • Direct Targeting of the Ventral Intermediate Nucleus Using High-field Proton Density MR Imaging: Functional Outcomes and Comparison to “Indirect” Targeting – Francisco A. Ponce
  • Blood-Brain Barrier Opening in Alzheimer’s Disease Using MR-guided Focused Ultrasound – Ying Meng
  • BEST RESEARCH TALK: Neural Control of Individual Finger Movements Using Intracortical Recordings from a Person with Tetraplegia – Ahmed Jorge
  • Functional Use of Directional Local Field Potentials in Parkinson’s Disease – Ilknur Telkes
  • Risk Analysis of Hemorrhages in Stereoelectroencephalography Procedures – Robert McGovern
  • A Novel Computational Approach in MATLAB to Characterize Thermal Damage Estimate in Magnetic Resonance-guided Laser Interstitial Thermal Therapy – Allison Liang

Wednesday, October 23

  • Stereotactic and Functional Sunrise Session and Late-breaking Abstract Session
    Emad Eskander
    and John Willie moderated.
  • Clinical Trials in Epilepsy Surgery
    Aviva Abosch directed the course, which identified key trials and levels of evidence for resective epilepsy surgery and described the relative advantages and evidence supporting neuromodulation procedures, including VNS, DBS and RNS. Faculty included Jorge A. Gonzalez-Martinez, Robert E. Gross and Timothy H. Lucas.